The role of IRF5 as an immune regulator
Published online 24 September 2026; assigned to the 28 October 2026 issue.
Publications
Journal publications authored by Betsy J. Barnes and Lionel Blanc. Shared papers appear in both lists.
Updated
Barnes Lab
Laboratory of Autoimmune and Cancer Research
Betsy J. Barnes, PhD
A pathogenic gut lipoglycan drives systemic thromboinflammation in lupus nephritis
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis
Shared paper
TLR-induced STK25 activation promotes IRF5-mediated inflammation
Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients
Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study
IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger
IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation
Shared paper
Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential
Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis
Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice
Shared paper
The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection
A New Methodology for the Quantification of Neutrophil Extracellular Traps in Patient Plasma
Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions
Shared paper
Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis
Shared paper
Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk
HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation
Shared paper
Neutrophil phenotypes and functions in cancer: A consensus statement
The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial
Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus
Intracellular IRF5 Dimerization Assay
Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells
Inhibition of IRF5 hyperactivation protects from lupus onset and severity
The Versatility of Sirtuin-1 in Endocrinology and Immunology
Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series
CD4 T Follicular Helper Cells Prevent Depletion of Follicular B Cells in Response to Cecal Ligation and Puncture
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Neutrophil extracellular traps in COVID-19
Potential T Cell-Intrinsic Regulatory Roles for IRF5 via Cytokine Modulation in T Helper Subset Differentiation and Function
Targeting potential drivers of COVID-19: Neutrophil extracellular traps
Modulating Cytokine Production via Select Packaging and Secretion From Extracellular Vesicles
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization
IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE
Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis
HMGB1-C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis
RNAi Transfection Optimized in Primary Naïve B Cells for the Targeted Analysis of Human Plasma Cell Differentiation
Genetic Versus Non-genetic Drivers of SLE: Implications of IRF5 Dysregulation in Both Roads Leading to SLE
Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes
Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability
Corrected and republished in 2018. The 2013 original was retracted; the retraction notice links to this replacement. Publication notice
B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation
Interferon regulatory factor 5 (IRF5) suppresses hepatitis C virus (HCV) replication and HCV-associated hepatocellular carcinoma
Interferon regulatory factor signaling in autoimmune disease
Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality
Constitutive expression of IRF-5 in HTLV-1-infected T cells
A conserved region within interferon regulatory factor 5 controls breast cancer cell migration through a cytoplasmic and transcription-independent mechanism
IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5(+) B- and T-cell trafficking to tumor-conditioned media
TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms
Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers
B cell transcription factors: Potential new therapeutic targets for SLE
Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis
Editorial: are regulatory B10 cells a viable target for autoimmune diseases?
Bioinformatics analysis of the factors controlling type I IFN gene expression in autoimmune disease and virus-induced immunity
RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE
Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus
Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching
Diverging antioxidative responses to IGF-1 in cultured human skin fibroblasts versus vascular endothelial cells
Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons
Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis
Modulation of interferon regulatory factor 5 activities by the Kaposi sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3 contributes to immune evasion and lytic induction
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression
Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus
IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
Interferon regulatory factor-5-regulated pathways as a target for colorectal cancer therapeutics
Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death
Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection
Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
An erratum is indexed in J Exp Med. 2003;198(9):following 1450. Publication notice
Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells
Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes
Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes
On the role of IRF in host defense
Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: potent inhibitors of human type II inosine 5'-monophosphate dehydrogenase
Induction of Tmolt4 leukemia cell death by 3,3-disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2-4-diones: specificity for type II inosine 5'-monophasphate dehydrogenase
Cytotoxicity of 2-aldo- and 2-ketopyridine-N(4)-substituted thiosemicarbazones and mode of action in human Tmolt4 cells
Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death
Targeting of human Tmolt4 leukemic type II IMP dehydrogenase by cyclic imide related derivatives
Specific inhibition of type II inosine monophosphate dehydrogenase activity of Tmolt4 T cell human leukaemia cells by 3-methoxy and di-benzohydroxamic acids, maleic hydrazide and malonic acids
Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes
Tmolt4 leukemic type II isoform of IMP dehydrogenase as a target for 1,2,4-triazolidine-3,5-diones, 1-(1-(3-methylphenyl)ethylidineamino)-4,4-diethyl-3,5-azetidinediones, 3,5-isoxazolidinediones, and 4,4-disubstituted-3,5-pyrazolidinediones
Effects of N-substituted phthalimide, saccharin, succinimide, and indandione derivatives on the type I and II isoforms of human TMOLT4 T cell IMP dehydrogenase
Cytotoxicity and mode of action of 1-(1-cyclohexenyl) and 1-unsubstituted 3,5-pyrazolidinediones in human Molt4 T cell leukemia
Analysis of the in vitro inhibition of murine and human tumor cell growth by pyrazole derivatives and a substituted azabicyclo [3.1.0] hexane-2,4-dione
Selective inhibition of human Molt-4 leukemia type II inosine 5'-monophosphate dehydrogenase by the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones
Cytotoxicity of rhenium(I) alkoxo and hydroxo carbonyl complexes in murine and human tumor cells
The cytotoxicity of trifluoromethyl boron derivatives and mode of action in human Tmolt3 T leukemic cells
Cytotoxicity of tantalum(V) and niobium(V) small carborane complexes and mode of action in P388 lymphocytic leukemia cells
The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats
Blanc Lab
Laboratory of Developmental Erythropoiesis
Lionel Blanc, PhD
With or Without You: Do Human EBIs Need a Central Macrophage?
Effects of transcutaneous auricular vagus nerve stimulation or combined vagal and trigeminal nerve stimulation on platelet function and laboratory hemostasis parameters in healthy human subjects.
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis
Shared paper
IFN-I-Mediated Transcriptional Reprogramming Drives Myeloid-Skewed Hematopoiesis in Sickle Cell Anemia.
Longitudinal changes in haemoglobin, iron stores, and inflammatory markers following surgery and in critical illness: an analysis from the Practical Anaemia Bundle for Sustained Blood Recovery randomised clinical trial.
Comprehensive Phenotypic and Proteomic Analyses of Human Reticulocyte Maturation.
BMI1 regulates human erythroid self-renewal through both gene repression and gene activation.
DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death.
Metabolic gatekeeping in murine stress erythropoiesis.
CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia.
IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation
Shared paper
Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways.
HEXIM1 is an essential transcription regulator during human erythropoiesis.
Parasite hijacks red cell membrane proteins.
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice
Shared paper
Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg.
Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice.
Targeting of Calbindin 1 rescues erythropoiesis in a human model of Diamond Blackfan anemia.
Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A.
Crosstalk between terminal erythropoiesis and granulopoiesis within their common niche: the erythromyeloblastic island.
Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions
Shared paper
An RPS19-edited model for Diamond-Blackfan anemia reveals TP53-dependent impairment of hematopoietic stem cell activity.
Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis
Shared paper
Defending the island against excess heme.
HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation
Shared paper
Extracellular 20S proteasome secreted via microvesicles can degrade poorly folded proteins and inhibit Galectin-3 agglutination activity.
Blood cells molecules and diseases in 2022: A fountain of youth.
αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability.
Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment.
Comprehensive phenotyping of erythropoiesis in human bone marrow: Evaluation of normal and ineffective erythropoiesis.
An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism.
Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia.
Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis.
Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.
Crossref records a publisher version update dated January 8, 2021. Publication notice
VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects.
Steroid resistance in Diamond Blackfan anemia associates with p57Kip2 dysregulation in erythroid progenitors.
Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models.
Is the erythropoietin receptor the key to the identification of the central macrophage in erythroblastic islands?
Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis.
Stress erythropoiesis: selenium to the rescue!
Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat.
Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability.
A published correction accompanies this article (June 2018). Publication notice
Erythropoiesis: insights into pathophysiology and treatments in 2017.
Developmental differences between neonatal and adult human erythropoiesis.
New insights into the function of Rab GTPases in the context of exosomal secretion.
Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology.
Unraveling Macrophage Heterogeneity in Erythroblastic Islands.
Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome.
Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis.
Molecular convergence in ex vivo models of Diamond-Blackfan anemia.
A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
A published erratum corrects an author name (2016). Publication notice
HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors.
Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors.
Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation.
The erythroblastic island as an emerging paradigm in the anemia of inflammation.
Poly(I:C) induces controlled release of IL-36γ from keratinocytes in the absence of cell death.
CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain.
Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells.
Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model.
EVpedia: a community web portal for extracellular vesicles research.
Diamond Blackfan anemia: a model for the translational approach to understanding human disease.
p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.
Republished on April 10, 2014 to correct typesetting errors; a publisher correction notice is available. Publication notice
Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome.
HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.
Expression of concern. A 2020 corrigendum identifies unreliable mass-spectrometry data in Figure 3; read the publisher notices with this article. Publication notice